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UK Researchers Create 3D Printed Phantom Inserts for More Accurate, Customized Dosage in Molecular Radiotherapy

by • July 14, 2016 • No Comments

Schuster Laboratory at the School of Physics and Astronomy at The University of Manchester

Schuster Laboratory at the School of Physics and Astronomy at The University of Manchester

Molecular radiotherapy is a crucial part of treatment for many patients suffering of cancer and other conditions, generally with the goal being to send radiation to tissue exhibiting malignancy. MRT is yet an evolving discipline, but one that is expanding rapidly. And now, researchers are via 3D printing to additional the progress of this type of treatment.

Just published in EJNMMI Physics, authors Andrew P. Robinson, Jill Tipping, David M. Cullen, David Hamilton, Richard Brown, Alex Flynn, Christopher Oldfield, Emma Page, Emlyn Price, Andrew Smith, and Richard Snee outline their findings in ‘Organ-specific SPECT activity calibration via 3D printed phantoms for molecular radiotherapy dosimetry.’

As 3D printing has created massive strides inside the medical field may already, looking in the direction of a next of patient-specific treatment, researchers are examining how this can be applied on many levels. In this context, the scientists of the Schuster Laboratory at the School of Physics and Astronomy at The University of Manchester were concerned with customized, absorbed dose calculations for molecular radiotherapy, and how to complete the many accurate activity quantification. The traditional system relies on Single-Photon Emission Computed Tomography (SPECT) imaging. With SPECT, counts are detected regarding activity in phantom inserts, Camera-specific calibrations are frequently relied on as well due to the intrinsic and ‘many quantitative inaccuracies’ discovered in SPECT imaging.

“Calibration facts determined of physical phantom data are highly dependent on the specific geometry and activity distribution being considered,” say the researchers in their paper. “The geometry of phantom inserts utilized for SPECT activity calibration is frequently far removed of both the clinical situation and the mathematical versions that provide the basis of the many common MRT dosimetry calculations.”

According to the researchers, who point out that the MIRD schema (created so that medical professionals may calculate mean absorbed dose of distributed sources of radioactivity) is the just FDA-approved general MRT dosimetry code, with access to phantoms enabling for additional ‘approximate clinical MRT distributions,’ there is excellent future for accurate patient-dosimetry that should be on the market to any center offering the radiotherapy. This means that dosages may be calculated in regards to the patient’s age, sex, and with consideration to their individual organ masses.

With 3D printing, the researchers were able-bodied to manufacture the phantoms inserts on a Stratasys Dimension Elite 3D printing device. Made with 2mm thick walls, or 3mm for the liver version as it is larger, the researchers fill the inserts with a radioisotope solution.


Figure One.

The team created inserts for all ages, of that of liver versions for adults to inserts that may be appropriate for kidneys in those of ages five to ten. In the adult version, they were able-bodied to add to extra lobes as well as a 16 ml tumor (see Figure One).

In testing, the researchers discovered the phantom inserts, printed in ABS, to be quite effective, with calibration facts revealing a 24%, 11% and 8% reduction in absorbed dose for the liver, spleen, and kidneys, respectively. Stating the results were recreated accurately with Gaussian kernel based calculations over two orders of magnitude alter, the researchers had a quite positive conclusion.

“These results highlight the future for individualized whole organ activity quantification, corresponding to patient organ VOIs [volumes of interest], to improve accuracy in whole organ dosimetry,” sayd the researchers.

“The competence for clinical centres to test SPECT systems with activity distributions that represent the mathematical versions underlying MIRD schema dose calculations is a crucial step in establishing validated MRT dosimetry.”

They point out that these inserts should be easily accessible for medical centers actually without their own printing device, as they can send them out to a local service bureau for fabrication. With the competence to create these customized inserts on their own—whether via their own machine printing in ABS or another—the researchers are hopeful that clinical centers equitewhere should be able-bodied to manufacture these as routine practice actuallytually. As the phantoms assist provide advantageous calibration, additional accurate dosages can be maintained overall.

[Source: 7th Space Interactive]


Figure Two. From the researcher’s paper: Ratio of VOI calibration factor (cf voi ) to true camera sensitivity calibration factor (cf true ), as a function of number of voxels in VOI (nVoxels). Data is shown for phantom measurements (blackand green squares) and corresponding calculated values (red circles) (Eq. 7). The plotted standard uncertainties include a ±1 voxel (4.42 mm) uncertainty in positioning the VOIs.