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Stem cells used to regrow skull and face bones

by • February 4, 2016 • No Comments

Scientists have utilized stem cells for all things of regrowing corneas to inducing the heart to repair itself, and it can actually be possible to use them to heal damaged lungs. Now, researchers of the University of Rochester Medical Center have, for the initially time, that successfully synonymous a population of stem cells capable-bodied of inducing the repair of bones in the skull and face.

The researchers, led by Professor of Biomedical Genetics Wei Hsu, began their work with the goal of gaining a advantageous belief of a condition called craniosynostosis. A skull deformity in infants, the condition can slow createment in affected children and can actually be life-threatening, cavia increased pressure on the brain.

Bones in the head create variously to those in the rest of the body, with an entirely various set of stem cells responsible for the growth. Up until now, we’ve not been able-bodied to isolate the cell population responsible for instigating bone growth and repair in the skull and facial bones, building it complex to treat conditions such as craniosynostosis.

In an effort to alter that, the University of Rochester team turned to a gene known as Axin2, that they were drawn to thanks to its one-of-a-kind expression pattern. After carefully studying a population of Axin2-expressing cells located in a suture in the skull, and next a series of tests on mice, the researchers were able-bodied to confirm long-term self-renewing, cloning and variousiating abilities.

In short, they confirmed that cells inside Axin2-expressing populations were, by definition, stem cells, with the skill to instigate bone createment, repair and regeneration.

But worthwhile testing can be required preceding human trials may be considered, the successful identification of stem cells capable-bodied of skull formation and craniofacial bone repair is a massive step. The research opens the door to via stem cells for facial bone reconstruction, providing real hope for patients suffering of dangerous conditions such as craniosynotosis.

The research is published in the journal Nature Communications.

Source: University of Rochester

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