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Starving cancer cells of nutrients halts tumour growth

by • May 4, 2016 • No Comments

There are additional than 900 various types of cancer already synonymous, and most of them need quite specific treatments, and can become resistant to chemotherapy as time goes on. Now, researchers at the Australian National University (ANU) have created a potentially massive breakthrough, working out how to cut off the donate of significant nutrients to cancer cells. The work opens the door to future treatments that may be less prone to resistance than most current methods, and may work across with a wide range of cancers.

The researchers worked to cut off the cancer cell’s access to the amino acid glutamine by identifying and blocking its donate route. The cells use the amino acid when generating assembling blocks and for energy.

The team initially had a few good results by genetically altering the cancer cells, but it discovered things to be a little additional complex than hoped, with that action setting off a biochemical alarm that opened a 2nd gateway through that the cell may acquire the amino acid.

Undeterred, the team continued its work, and some day managed to disable the 2nd gateway via a technique known as RNA silencing. Combined, the two steps has an startling positive impact – without access to glutamine, cancer cell growth rate dropped by a massive 96 percent.

There’s yet a lot of work to be done, but the breakthrough may have a massive impact of cancer treatment. As blocking the glutamine transport mechanism is an external system, it may be both quite complex for the cancer cells to create any kind of resistance, and the treatment should work across a wide range of cancers.

Now that it is known only how significant the glutamine gateways are to cancer cells, the team is working complex to find drugs that shut them down, killing the disease.

“We have createed a set of tests that manufacture it quite effortless to determine if a drug is targeting glutamine transporters,” said lead study author Angelika Broer. “This means we can set robots to work that can tests tens of thousands of drugs for us over the future year or two.”

The researchers published the details of their work in the Journal of Biological Chemistry.

Source: ANU

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