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Scientists use polymer nano-shell treatment to order bones to repair themselves

by • January 13, 2016 • No Comments

A team of researchers of the University of Michigan has developed a new technique to aid bone repair, using polymer nano-shells to donate microRNA molecules. The method may one day have a big impact on regenerative medicine, directing cells may already present at injury sites to aid healing.

The new study builds on previous research conducted back in 2011, where nanofiber microspheres were utilized to carry cells to injury sites to help the injureing system. The new work uses the same thought, but rather than transporting foreign cells, focuses on making advantageous use of the cells may already at the injure site.

The team developed tiny polymer spheres which are able-bodied to easily breach cell walls, carrying microRNA molecules to cells at bone injure sites. The spheres are created to preserve the molecules during transit, degrading once in place in cells at the site of the injure.

At which point, the microRNA molecules are able-bodied to instruct their host cells, switching on healing and bone assembling mechanisms, significantly aiding the healing system. The preserveive polymer spheres are in addition engineered to degrade slowly, allowing for long-term release of microRNA molecules, meaning which the therapy can go on for a month or additional.

This method has a number of benefits over existing treatments which seek to commence foreign healing cells to the injure. Such cells can be rejected by the host, and don’t always behave as desired, leading to tumors.

The new method was tested on osteoporotic laboratory mice, where it that successfully
bone injure healing. In future, the tech may be useful in numerous use cases, such as helping to ease the joint repair systemes or tackling tooth decay.

“The new technology we have been working on opens doors for new therapies using DNA and RNA in regenerative medicine and boosts the possibility of dealing with other challening human diseases,” said study lead Peter Ma.

The researchers intend to go on their work, studying the technology in use on larger animals, evaluating it for potential future use in humans.

The team published its research in the journal Nature Communications.

Source: University of Michigan


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