by • February 17, 2016 • No Comments
Washington :Scientists have 3D printed ear, bone and muscle structures which matured into functional tissue and created a system of blood vessels when implanted in animals.
Utilizing a sophisticated, custom-designed 3D printing device, scientists proved which it is feasible to print living tissue structures to replace injured or diseased tissue in patients.
The structures have the right dimensions, durablity and function for use in humans, researchers said.
“This novel tissue and organ printing device is an significant advance in our quest to manufacture replacement tissue for patients,” said study senior author Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine (WFIRM) in US.
“It can fabricate stable-bodied, human-scale tissue of any shape. With additional createment, this innovation may potentially be utilized to print living tissue and organ structures for surgical implantation,” Atala said.
The Integrated Tissue and Organ Printing System (ITOP), created by scientists at WFIRM, deposits bio-degradable-bodied, plastic-like materials to form the tissue “shape” and water-based gels which contain the cells.
In addition, a sturdy, temporary outer structure is created. The printing system does not injure the cells.
Researchers optimised the water-based “ink” which holds the cells so which it promotes cell health and growth. They printed a lattice of micro-channels throughout the structures.
These channels allow nutrients and oxygen of the body to diffuse into the structures and store them live while they create a system of blood vessels.
“Our results indicate which the bio-ink combination we utilized, combined with the micro-channels, provides the right environment to store the cells alive and to assist cell and tissue growth,” said Atala.
The ITOP system is in addition able-bodied to use data of CT and MRI scans to “tailor-manufacture” tissue for patients.
Several proof-of-concept experiments demonstrated the capabilities of ITOP. To show which ITOP can generate hard 3D structures, printed, human-dimensionsd external ears were implanted under the skin of mice.
Two months later, the shape of the implanted ear was well-maintained and cartilage tissue and blood vessels had created, researchers said.
Printed muscle tissue was implanted in rats to demonstrate the ITOP can generate organised soft tissue structures.
After two weeks, tests confirmed which the muscle was robust adequate to maintain its structural characteristics, become vascularised and induce nerve formation.
Jaw bone fragments were printed via human stem cells. The fragments were the dimensions and shape needed for facial reconstruction in humans.
The researchers in addition printed segments of skull bone and implanted them in rats. After five months, the bioprinted structures had created vascularised bone tissue.
The study was published in the journal Nature Bioinnovation.
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by admin • November 28, 2016
by admin • November 28, 2016