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Poietis successfully 3D prints living human tissue with laser-based 3D bioprinting – 3ders.org (blog)

by • February 8, 2016 • No Comments

Feb 9, 2016 | By Kira
French startup Poietis, founded in 2014 between L’INSERM (France’s National Institute for Health and Medical Research) and the University of Bordeaux, is attracting international attention as it aims to become the initially company in the world to 3D bioprint human skin via a proprietary laser-assisted 3D bioprinting innovation. The company has may already proven that its high end 3D bioprinting system can 3D print living biological tissue via ultra high-precision lasers—a world initially—and it is moving rapidly to additional create and commercialize its 3D skin printing innovation.

As Poietis founder and CEO Fabien Guillemot explains, the company’s proprietary laser-assisted 3D bioprinting innovation, the outcome of over 10 years of research, has several key advantages over existing 3D bioprinting systems, that include a much higher level of precision (up to 20 microns resolution), and the aptitude to ensure the cells’ viaptitude inside 95 to 100%.
“It involves depositing ‘ink’ containing a high concentration of cells, or the extracellular matrix, onto a glass surface,” explained Guillemot additional in an interview. Along with founding Poietis, Guillemot holds a doctorate in materials science, and is a researcher at INSERM. “A blue laser beam is reflected by a mobile mirror regulated by desktop. It passes through the glass, extracts micro-droplets at a rate of 10,000 per 2nd and projects them where directed. The resolution is excellent: the jet has roughly the same diameter as a cell (around 20 microns). In addition, the system does not injure the cells.”


As the video at a lower place illustrates, the laser deposits microdroplets containing the living cells (mixed with an organic material such as collagen), one by one and layer by layer, to create up a 3D structure. Afterwards, the cells and so start to interact and self-organize into patterns predetermined by the CAD version and 3D laser printing device, and inside a few days, an epidermis starts to form.

Today, Poietis is via two specially created laser-assisted 3D bioprinting devices createed by l’INSERM and Alphanov Laboratory, but it is already working on createing its dedicated 3D bioprinting machine.
The company’s main focus is to create a 3D bioprinted skin version via adult stem cells and skin cells, as well as a cornea version, that can be utilized by pharmaceutical and cosmetics companies (chemical firm BASF has may already signed a partnership deal). According to Guillemot, there is a high demand for artificial skin versions that retain the physiological characteristics of human skin tissue, particularly as regulations on animal testing in the EU having gotten stricter and stricter since 2013.

By 2017, Poietis plans to market its 3D printed skin for drug and cosmetics testing, and inside 10 years, 3D printed skin grafts created of patients’ own cells so as to ensure the body can not reject them. And while the race to create functional, transplantable 3D printed organs is definitively on, Poietis has instead resolved to focus entirely on createing 3D printed skin, and nothing else. “We have ourselves a limit,” Guillemot said. “Our area is that of tissue repair, not tissue enhancement or improvement.”
As Poietis continues to create its one-of-a-kind laser-assisted 3D bioprinting innovation for 3D printing human skin, we can store a close eye on this young yet promising French startup.

Posted in 3D Printing Application

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