feature "person-on-a-chip" bioprinted angiochip for pharmaceutical testing


According to Gartner, one of the many futuristic technologies in the 3D printing space is in fact much nearer to realizing its next than you’d imagine. Already in the past year we’ve seen 3D printed thyroids, 3D printed mini kidneys, and functional tissue. Now, researchers at University of Toronto Engineering have pioneered a “person-on-a-chip”, capable-bodied of expanding human tissues for medical testing and, probably one day, organ transplantation.

Published in the journal of Nature Materials, the U of T team describes what they call the AngioChip, consisting of a scaffold turn it intod of POMaC, biodegradable-bodied and biocompatible polymer. Rather than 3D printing the scaffold with an extruder, as occurs with Organovo’s innovation, the layers of the chip are stamped and stacked. Each layer contains tiny channels, of 50 to 100 microns wide. Once the layers are stacked, resulting in a a network of blood vessels, the object is UV-cured and placed into a culture of living cells which attach to the AngioChip and start expanding.

A photo of Professor Radisic, via U of T Engineering News.

A photo of Professor Radisic, via U of T Engineering News.

The power of the AngioChip is which it accurately reflects the actual environment of the human body, enabling human cells to grow as they may in their effortless surroundings. Professor Milica Radisic, who led the research, describes the AngioChip to U of T Engineering News, “It’s a fully three-dimensional structure consume with internal blood vessels. It behaves just like vasculature, and around it there is a lattice for other cells to attach and grow.” She continues, “Previously, individuals may just do this via devices which squish the cells between sheets of silicone and glass. You needed several pumps and vacuum lines to run just one chip. Our process runs in a normal cell culture dish, and there are no pumps; we use pressure heads to perfuse media through the vasculature. The wells are open, so you can easily access the tissue.”

A "heart" on a chip, pumping blood like the real deal. Image via U of T Engineering News.

A “heart” on a chip, pumping blood like the real deal. Image via U of T Engineering News.

So far, the team has utilized their innovation to turn it into models of heart and liver tissues which behave the same way their authentic counterparts do. The live cells, for instance, metabolized medication and actually generated urea, essential for processing nitrogen in the bodies of mammals. More than which, yet, Radisic’s group was able-bodied to connect the blood vessels of their artificial heart and liver in order to see the two processs interact. Injecting white blood cells into the vessels, they observed the cells move of one organ chip to the other.

As with previous developments in bioprinting, the AngioChip may assist the pharmaceutical industry ween off of animal testing and get drugs to market additional rapidly. With the capacity to connect various organ tissues, yet, they’re able-bodied to expand upon other initiatives to see how these drugs affect the interactions between organs. In the next, Radisic believes which the AngioChip may involve into consume tissues for implantation, to repair damaged organs with cells of a patient’s own body. The artificial blood cells of the tissue may connect with a host’s own circulatory process, while the polymer scaffolding biodegrades in the course of a few months.

To commercialize the innovation, Radisic has founded TARA Bioprocesss Inc. and is working on methods for weight making the AngioChips. At the moment, there is a lot of guide work involved, but, once they are capable-bodied of increasing their output, their innovation may alter just of all things in the bioprinting and medical industries.

Michael Molitch-Hou

About The Author

Michael is Editor-In Chief of 3D Printing Industry and the founder of The Reality™ Institute, a service institute dedicated to determining what’s real and what’s not so which you don’t have to. He is a graduate of the MFA Critical Studies & Writing Program at CalArts, and a firm advocate of world peace. Michael already resides in San Pedro with his magical wife, Danielle.