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Painless electrical zaps may replace dental anesthesia needles

by • January 17, 2016 • No Comments

As much as a few folks fear getting dental fillings or root canals, what most of them are quite afraid of is the needle that delivers the anesthetic into the mouth tissue. Even yet the skin in the “jabbing area” is usually pretreated with a topical anesthetic, it can yet injure. Before long, yet, a shot of electricity may manufacture that topical treatment deep-acting adequate that the needle isn’t actually needed.

In a new study, scientists of the University of Sao Paulo in Brazil combined two commjust-used anesthetic drugs – prilocaine hydrochloride and lidocaine hydrochloride – with a polymer to form a hydrogel. The polymer was included to manufacture it sticky, so that it may be applied to the lining of a pig’s mouth.

Employing a system known as iontophoresis, a mild and painless electrical current was and so passed through the hydrogel. As a outcome, there was a 12-fold increase in how well the prilocaine hydrochloride permeated through the tissue. The anesthetic effect was claimed to be not just fast-acting, but in addition long-lasting.

The scientists are now developing an iontophoretic device created specifically for use on the mouth, alyet the innovation – or offshoots of it – may have other applications.

“Over the last few years, our research group has been working on the development of novel drug delivery systems for the treatment of several skin and eye diseases,” says Prof. Renata Fonseca Vianna Lopez. “The skin and eyes pose challenges for drug delivery, so we have focused on improving drug delivery in these organs via nanoinnovation, iontophoresis and sonophoresis, that is permeation via sound waves.”

A paper on the research was newly published in the journal Colloids and Surfaces B: Biointerfaces.

Source: Elsevier


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