When the thought of a medical transplant is brought up, many people’s thoughts are usually drawn to procedures such as blood transfusions or organ replacements. But, oftentimes, we forget the importance of our bone structure, as well as the 2 million painful bone transplants that take place every year around world. Previously stuck in a Medieval-like operation method, surgeons had little version but to replace their patients’ bones with the bones of animals or human cadavers, and actually this procedure can oftentimes led to complications due to the body’s rejection of the foreign replacement. But 3D bioprinting has been a primary effects in changing the entire nature of this traditional surgical procedure, new methods of creating bone grafts have been created by researchers around the world of Montana State University to Tokyo. 3D printing has become a new revelation in skeletal reconstruction surgery, with 3D printed synthetic implants and actually harvested stem cell materials proving to be a much safer and efficient surgical alternative.
EpiBone CEO Nina Tandon with CSO Sarindr Bhumiratana
One NYC-based startup called EpiBone is bringing these biomaterials to a new level, working to ensure the good results of bone replacement surgery by creating biomaterial of every patient’s own stem cells. After bringing a CAT scan, that EpiBone CEO Nina Tandon says is ‘essentially a high-resolution 3D X-ray’, a personalized 3D printed scaffold is created in the precise shape of the bone being targeted for repair. EpiBone plans to extracts the stem cells via a sample of the patient’s fat, that is and so infutilized with the 3D printed scaffold. The stem cell-infutilized scaffold is and so placed into a ‘bioreactor’, that is a special growth chamber that imitates the condition of the human body (such as temperature, humidity, acidity, and nutrient composition) to allow the stem cells to alter into osteoblasts, that are the bone-growing cells needed for the accomplished living bone replacement.
After three weeks in the bioreactor, the scaffold becomes colonized with living tissue, creating a perfectly shaped bone replacement created of the patient’s body, that EpiBone hopes can greatly reduce the accident of cavia rejection in the body. Tandon is an extreme advocate of introducing stem cells into medical treatment, and as 3D bioprinting continues to expand, I can just assume the faculty to properly commence stem cells into medical procedures to expand as well. “What’s many inspiring to me of the evolving science of regenerative medicine is how it recasts the role and future of the body’s own cells,” Tandon said in Live Science. “No longer seen just as the passive subjects of treatments, cells are now active agents. They are collaborators. And they are the kind of naturally powerful actors that you really want on your team.”
So far, EpiBone has succeeded in implanting these artificial bones into pigs and other animals, but has yet to prove the good results in a human subject. But this research is a future breakthrough for skeletal reconstruction, Tandon believes that their work at EpiBone can actuallytually expand beyond both bone replacements and the medical industry as a whole. “If we can work in concert with living cells to grow bone, we can in addition adapt cells to revolutionary new uses in other realms of medicine, or actually entirely various fields, such as architecture, art and fashion,” she introduced. Tandon and the EpiBone team acknowledge that they have additional work to do preceding their one-of-a-kind bone replacement system is utilized on human patients, but their research thus far should have surgeons excited for a procedure that is traditionally really uncertain and grim.