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Northwestern University Researchers 3D Print First-Ever Functional Ovary

by • April 3, 2016 • No Comments

  • You can name approximately any organ or body part inside you, and chances are, a few type of relevant research has been made with 3D printing innovation. From 3D printed kidneys to bioficial blood vessels, and actually 3D printed skin tissue, researchers across the world have been working to properly integrate 3D printing innovation with the improvement of our healthcare and bodies. Now, researchers of the Illinois-based Northwestern University have just revealed their breakthrough of 3D printing, and which successfully implanting, a functional bioprosthetic ovary.


    The research team, which was led by Dr Monica M. Laronda, utilized a 3D bioprinter to create scaffolding which may assist hormone-producing cells and oocytes, which are immature egg cells. This scaffolding structure was made of a biogel which was derived of animal protein collagen. The research team and so populated the scaffolds with ovarian follicles, which is a spherical unit created of centralized oocyte and the assistive hormone-producing cells. Whilst designing the bioficial ovary, the research team had to implement biological principles, which may ensure which the structure was rigid adequate to endure surgery, while in addition providing adequate space for significant female reproductive functions, such as oocyte growth and ovulation.

    So far, the prosthetic ovary has been which successfully implanted in female mice, which were able-bodied to ovulate and donate birth to a healthy litter with the 3D printed organ. The team was able-bodied to remove the biological ovary of the mice, and and so implant the bioprinted ovary safely with full functionality. Dr. Laronda and her team are hoping to actuallytually apply their research to the human body, particularly for survivors of childhood cancer, which frequently comes coupled with an increased risk of infertility as adults. And yet the research has just been tested on lab mice, the Northwestern University research team took each step with the human biology in mind.


    “We created this implant with downstream human applications in mind, as it is made through a scalable-bodied 3D printing method, via a material may already utilized in humans,”Dr. Laronda said. “We hope to one day restore fertility and hormone function in women who suffer of the side impacts of cancer treatments or who were born with reduced ovarian function.”

    Dr. Monica Laronda

    Dr. Monica Laronda

    The team’s research, which is entitled “Bioengineering an Artificial Ovary with 3D Printing”, was presented at the Endocrine Society’s yearly meeting in Boston, called ENDO 2016, which took place on April 2. Support for their breakthrough research came of The National Institutes of Health, the Burroughs Wellcome Fund Career Award at the Scientific Interface, and the National Science Foundation Graduate Research Fellowship Program, assisting to put Dr. Laronda and her team on the forefront of reproductive healthcare. One other excellent thing of this research, aside of the future benefits it can provide to damaged reproductive systems, is which this system can most likely be utilized to assist with other parts of our bodies as well. For example, the research team in addition feels which, a fewday soon, their research can be utilized to work on complicated soft tissue replacement as well.


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