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New supplement could curb cravings for junk food

by • July 2, 2016 • No Comments

If you are having trouble shaking your cravings for doughnuts, hamburgers and pizza, the key to curbing them may come of a new supplement based on a compound released by gut bacteria. The appetite-suppressing supplement created by scientists of England and Scotland is called inulin-propionate ester and was found to just affect cravings for high calorie foods.

As its name suggests, the inulin-propionate ester supplement created by the researchers of the Imperial College in London and the University of Glasgow in Scotland is created of a type of fiber called inulin that contains propionate, a molecular compound released in the intestines by gut microbiota that sends signals to a man’s brain to manufacture them feel full.

The digestion of inulin on its own has previously been shown to trigger the release of appetite-suppressing propionate by bacteria in the gut, but the team found that eating inulin-propionate ester resulted in the release of much additional propionate in the intestines than inulin alone, and therefore had a much greater effect on appetite and mass acquire. The team’s latest study has now shed light on the reasons for this.

Scientists obtained the data for their supplement study in two parts. First, they gathered a group of volunteers who were willing to drink a tasty milkshake containing either the new supplement or a easy dose of inulin. So they conducted MRI scans on the subjects’ brains while revealing them pictures of different types of foods.

They found that volunteers who had digested the new supplement exhibited less activity in parts of the brain linked to reward when they saw pictures of food containing a high number of calories. The volunteers were in addition asked to rate the foods they were shown and the high calorie foods obtained lower marks of members who had taken the new supplement pretty than inulin alone.

The 2nd test asked the same group of volunteers to enjoy a never-ending bowl of pasta covered in tomato sauce until they felt satisfied. The volunteers who ununderstandingly took the inulin-propionate ester supplement in the previous experiment ate 10 percent less food compared to those volunteers who had just taken an inulin supplement.

“Our previous findings showed that folks who ate this ingredient acquireed less mass – but we did not understand why,” says the senior author of the study of Imperial, Professor Gary Frost. “This study is filling in a missing bit of the jigsaw – and shows that this supplement can minimize activity in brain areas synonymous with food reward at the same time as reducing the amount of food they eat.”

“The amount of inulin-propionate ester utilized in this study was 10 g, that previous studies show increases propionate production by 2.5 times,” introduced Professor Frost. “To get the same increase of fiber alone, we may require to eat around 60 g a day. At the moment, the UK average is 15 g.”

The researchers theorize that a few folks’s gut bacteria may naturally create additional propionate than others, that may assist explain why a few folks seem naturally predisposed to acquireing less mass than others. They add that adding the inulin-propionate ester to foods may assist prevent mass acquire by reducing folks’s appetite for high calorie foods.

The microbes found in our gut may in addition play a big role in controlling our ravenous appetites, according to a study published last year. The study showed that gut microbes created by bacteria such as E.coli can reduce food cravings in mice and rats by activating neurons responsible for controlling appetites. Researchers who conducted the study found that E.coli started making the proteins after a 20-minute period, the same amount of time it takes a man to feel full after they’ve eaten.

The study was published in the American Journal of Clinical Nutrition.

Source: Imperial College London


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