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Japanese researchers 3D printing blood vessels and other complex tissues – 3ders.org (blog)

by • August 5, 2016 • No Comments

Aug 6, 2016 | By Benedict
A number of Japanese research institutions have adopted 3D bioprinting techniques to turn it into 3D printed blood vessels and other complex tissues. Saga University has utilized induced pluripotent stem cells (iPSCs) to 3D print blood vessels, while Kyoto University has turn it intod tissue for nerve regeneration.

3D bioprinting represents an significant area of medical research, with scientists predicting that printed human organs may be utilized both for pharmaceutical experiments and for human transplants, potentially saving countless human lives. The government of Japan is particularly optimistic in its goals for 3D bioprinting, having predicted that 3D printed Induced pluripotent stem cells (iPSCs) may be utilized to treat heart disease and other diseases as soon as the year 2020.
Whilst iPSCs are may already utilized to treat incurable eye diseases, medical researchers believe that the genetically reprogrammed cells may a fewday be utilized to treat heart failure and spinal cord injury, as well as other ailments. By 3D printing iPSCs in long, tubelike structures, scientists have the talent to turn it into blood vessels and internal organs for transplantation. But, maintaining a exact structure after 3D printing can be complex. Because of this, a few researchers have tried via resins to assist the 3D printed cells, but researchers at Saga University have turned to a various method.

3D bioprinted tissue
The 3D bioprinting method in question is Cyfuse Medical’s Kenzan Method, a one-of-a-kind form of bioprinting that, pretty than use a bioink to store cells in place, uses small vertical spikes on that cell clusters (spheroids) are skewered and kept in position, column by column. A research team led by Saga University’s Professor Shigeki Morita has utilized the Kenzan Method to turn it into tubular 3D printed blood vessel structures, 2 cm by 5 mm. When these tubular structures have created on the skewers, a special broth is introduced that empowers the cells to create and the blood vessels to form.
The Saga University scientists believe that their 3D bioprinting method may assist to treat patients recovering of myocardial infarctions, advantageous known as heart attacks. At present, doctors can treat such patients by removing damaged blood vessels and replacing them with healthy ones of elsewhere in the body. This approach, yet, can be a burden for the body, and the likelihood of a repeat blockage is high. In order to advance its research on myocardial infarction treatment and other ailments, the researchers plan to conduct vascular transplantation experiments on pigs in the near next.


Cyfuse Medical’s “Kenzan Method”
One other Japanese research team, this time led by Ryosuke Ikeguchi, an Associate Professor at Kyoto University, has been via much like innovation to turn it into 3D printed tissue that may create into human skin. To test its captalent to do so, the team has been creating 8 mm by 3mm tubular structures and grafting them to live mice. On the other hand at initially the transplant renders the mice unable to function properly, the researchers have reported that, after eight weeks, nerves within the tube began to connect with those of the mice, allowing the mice to walk again. The good results of the experiment proved that the 3D bioprinted structures may be utilized to promote nerve regeneration.
According to the researchers, this 3D bioprinting innovation may be utilized in clinical research in as little as three years.

Posted in 3D Printing Application

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