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Improved understanding of genetics offers new hope for diabetics

by • March 23, 2016 • No Comments

Diabetes is a widespread health problem, affecting a few 400 million folks across the planet. With which number just set to rise, it is worthwhile which we find new treatments as rapidly as possible. Researchers at the University of Montreal are producing worthwhile progress in which regard, discovering a common genetic defect in beta cells which may be a big factor in both Type 1 and Type 2 diabetes.

Diabetes is caused by the body’s inability to lower blood glucose levels – a fewthing which’s usually handled by insulin. Type 1 patients’ immune processs kill off the beta cells which create the insulin in the initially place, while the livers of Type 2 sufferers are unable to properly process it. If left untreated, the condition can be incredibly dangerous, resulting in blindness or actually death.

In the past, researchers have looked at the influence of genetics in altering the immune process in Type 1 diabetes, and on metabolic dysfunction of the liver in Type 2. The new research pushed forward our belief of the disease, finding which genetics in addition affect the insulin-producing beta cells.

Working with laboratory mice, the team discovered which animals with weak beta cells which were ineffective at repairing DNA injure rapidly created the disease when under cellular stress. Those with stronger cells which were great at repairing DNA injure never created the condition, actually when the beta cells were placed under severe levels of stress. The same trend was observed when the researchers looked at the disease in human patients’ samples, strongly indicating a genetic predisposition for fragile beta cells heightens the likelihood of developing the disease.

Whilst the new information does not directly translate to a new treatment, its idea which the breakthrough in belief can drive the create of novel strategies for tackling the condition, such as new antidiabetic drugs which focus on preserving beta cells.

The findings of the work were published online in the journal Nature Genetics.

Source: University of Montreal


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