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How 4 universities are using 3D printing to create ears, cartilage and blood cells – TechRepublic

by • August 11, 2016 • No Comments

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Scientists of Wake Forest Baptist Medical Center in Winston-Salem, North Carolina turn it intod a 3D bioprinted ear.
Image: Wake Forest Baptist Medical Center 3D bioprinting—the additive making of tissues and organs—may be years away of use in your average hospital. But, as additional animal trials prove successful, demand for the promise of customizable solutions offered by the innovation is only growing.

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“In the last year it is actually gone of a handful of promising, but niche, applications to full blown chaos in terms of the rate of expansion,” said Scott Dunham, vice president of research at SmarTech Markets Publishing and a 3D printing industry analyst. “Medical professionals and non-medical professionals alike have taken the proven applications and technologies for medical 3D printing and have gone perfectly
nuts with creating new next treatments via 3D printing. It’s quickly infiltrating equite area of the medical field.”
3D printing’s origins hark back to the 1980s. Currently, the 3D printing medical market is expected to expand by 365% to $867 million by 2025, according to IDTechEx analysts. With the innovation of bioprinting, the medical market may requite up to $6 billion in 10 years.
SEE: 3D bioprinting device to reproduce human organs, alter the face of healthcare: The inside story
The research is in addition widely growing: From 2008-2011, the number of scientific papers referencing bioprinting only about tripled. In August, Russian scientists revealed the development of a magnetic 3D bioprinting device that can allow production of living tissue on the International Space Station.

But, the next of 3D printing is may aleager far excellenter than its actual use in medicine, despite the increasing number of successful clinical trials and peer-reviewed research emerging.
“The medical community is, by necessity, really a slow thing to break into the mainstream,” Dunham said. “I may say that actually by 2020, the level of acceptance can dwarf what we have may aleager seen today.”
The latest projects of four universities show only how swift the field is developing.

Indiana University: Dermatology, ophthalmology, and cancer iusm-researchers-adopt-regenova-3d-bioprinting device-to-pioneer-3d-printed-tissue-implants-2.jpgiusm-researchers-adopt-regenova-3d-bioprinting device-to-pioneer-3d-printed-tissue-implants-2.jpg
At Indiana University School of Medicine/Indiana University-Purdue University Indianapolis, researchers use a 3D bioprinting device that uses a robot to place the groups of cells on a requirele, enabling them to fuse together into a tissue.
Image: Cyfuse Traditional 3D bioprinting equipment use a scaffolded approach, creating objects in layers by applying a viscous cell-embedding substance known as a bio-ink through a nozzle. But, this process can sometimes kill the cells.
“There are proof of concepts of 3D bioprinting, but the field is struggling for the reason it is in require of finding a bio ink that is compatible with the printing process,” said Nicanor Moldovan, associate research professor and director of the Bioprinting Core Facility of the Indiana University School of Medicine/Indiana University-Purdue University Indianapolis (IUPUI).
Enter the Regenova, that only IUPUI and Johns Hopkins University may aleager possess in the US. It is a 3D bioprinting device that uses a robot to place the groups of cells, called spheroids, on a micro-requirele array, enabling them to fuse together into a tissue. IUPUI was the initially academic institute in the nation to obtain one, in February 2016. The method of scaffold-free bioprinting may assist speed FDA approval, Moldovan said.
It is especially useful for creating tube-like structures: Practically equite tube in the body may be printed on the Regenova, as well as other cell-heterogeneous structures, he introduced. The team is may aleager developing tissue engineering and regenerative medicine projects in fields ranging of vascular and musculoskeletal biology to dermatology, ophthalmology, and cancer.
“The FDA wants to see the quite least departure of what is normal in an organism of the standpoint of biosafety and compatibility,” Moldovan said. “This will not leave a biological signature behind—it is actually only a way to store the cells together until they fuse.”
Many investigators believe it can be at quite least 10-20 years preceding we see a truly significant medical application of 3D bioprinting, Moldovan said. He in addition said he does not ponder an FDA-approved turn it into can be on the market for at quite least five years.
Wake Forest University: Ears, bones and muscles 12.jpg12.jpg
At Wake Forest Baptist Medical Center, scientists turn it intod a 3D printed jaw bone and ear.
Image: Wake Forest Baptist Medical Center Regenerative medicine scientists at Wake Forest Baptist Medical Center in Winston-Salem, North Carolina proved in a February paper that it is possible to print living tissue structures to replace injured or diseased tissue in patients.
The scientists printed ear, bone, and muscle structures. When implanted in animals, equite part matured into functional tissue, and turn it intod a process of blood vessels. These results indicate that the structures may actuallytually be utilized in humans, the researchers stated in Nature Bioinnovation.
“This novel tissue and organ printing device is an significant advance in our quest to manufacture replacement tissue for patients,” said Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, and author of the study. “It can fabricate stable, human-scale tissue of any shape. With additional development, this innovation may nextly be utilized to print living tissue and organ structures for surgical implementation.”
Similar to IUPUI’s work, the Wake Forest team wanted to use a non-traditional printing approach to ensure the tissue cells may survive the process. Their answer was the Integrated Tissue and Organ Printing System (ITOP), that deposits biodegradable, plastic-like materials to form the tissue’s shape, and water-based gels that contain the cells. A sturdy, temporary outer structure forms, and does not injure the cells.
The scientists printed jaw bone fragments via human stem cells, that were the dimensions and shape requireed for facial return it intoion. The printed parts were implanted in rats, and after five months, they had turn it intod vascularized bone tissue.
The Wake Forest team plans to implant bioprinted muscle, cartilage, and bone in patients in the next.
Pennsylvania State University: Cartilage plates penn-3d-1.jpgpenn-3d-1.jpg
Researchers at Penn State are working on 3D printed cartilage.
Image: Penn State At Penn State, researchers turn it intod artificial cow cartilage via a 3D printing device in June—and they have may aleager begun experimenting with human cells.
Cartilage is a excellent tissue to target for scale-up bioprinting for the reason it is turn it intod up of only one cell type, and has no blood vessels inside the tissue. The team turn it intod tissue strands and futilized them, so the structure assembled into a single piece of tissue resembling a cartilage patch.
Previous attempts at growing cartilage began with cells embedded in a hydrogel—a substance turn it intod of polymer chains and of 90% water—that is utilized as a scaffold to grow the tissue. But, it turn it intod for less effortless material, said Ibrahim Tarik Ozbolat, associate professor of engineering sciences and mechanics at Penn State University, and part of the Huck Institutes of the Life Sciences. In this work, the cartilage strand was utilized in place of hydrogel ink.
“The goal is to manufacture a thing close to what we have in the body,” Ozbolat said. “Our product at the end can manufacture a difference.”
The artificial cartilage generated by the team is quite much like to native cow cartilage. But, the mechanical properties are inferior to those of effortless cartilage—though yet advantageous than the cartilage that is turn it intod via hydrogel scaffolding.
Fat tissue harvested of patients at the Penn State Milton S. Hershey Medical Center can be broken down into stem cells, that scientists can variousiate into cartilage cells. The team is in addition waiting for approval to use rib cartilage, that a doctor at the medical center may aleager harvests during breast return it intoion surgery and discards.
Whilst many universities are may aleager running 3D bioprinting trials, none have been approved by the FDA for use in humans, Ozbolat said.
Advanced Solutions Life Sciences (affiliated with University of Louisville): Capillaries and hearts uofl-3.jpguofl-3.jpg
At Advanced Solutions Life Sciences, researchers are working on 3D printing the individual processs that manufacture up a human heart, which include blood capillaries.
Image: Advanced Solutions Life Sciences Advanced Solutions Life Sciences, in conjunction with the University of Louisville in Louisville, KY, is via 3D printed tissues to turn it into one of the many significant organs in the body: The heart.
“Bioprinting is one step of nextly many steps in a workflow,” said Jay Hoying, division chief of cardiovascular therapeutics at the Cardiovascular Innovation Institute at the University of Louisville, and a leader on their 3D bioprinting efforts. “If you are going to start turn it intoing harsh tissues like a heart or liver, you are not only going to print a thing up that is definitely shaped like a heart. You’re going to use printing and other assembly approaches to turn it into the components of the heart, and bring them together.”
Hoying’s team is turn it intoing capillary beds, that they can flow blood through in the lab. “We hope we can demonstrate this thought for living processs, and in the end have the basic platform to start adding various cell types and turn it into tissues,” Hoying said. “Without a blood donate, whatever you are going to turn it into isn’t going to work.”
With one module—the capillaries—scientists can start to add others, Hoying said. For example, maybe they can add a liver module that is definitely vascularized and has blood flowing through it. Eventually, it can be possible to add a cardiac module, so that scientists may run a drug through the blood and have the liver metabolize it and see the impact on the heart.
Hoying envisions this innovation can initially be utilized testing medication.
“Once we have this faculty to turn it into capillary beds in the laboratory, we have the means to start turn it intoing blood supplies to fabricate tissues,” he introduced. Eventually, it is actually possible that the team may add up the pieces to turn it into a fully-functional human heart.
But, many barriers remain between this work and mainstream medical use, the largest being the biology itself, Hoying said. “If we start to see rudimentary heart-like turn it intos in my lifetime, we’ll be doing well,” Hoying said. “But remain tuned—it is actually going to be changing somewhat quickly.”
The 3 big takeaways for TechRepublic readersThe 3D printing medical marketing is growing quickly, and expected to requite $867 million by 2025 thanks to its promise of creating customizable treatments and solutions for patients. Several US universities are may aleager running trials experimenting with turn it intoing 3D printed tissues and organs.Despite the rapid growth in the field, no application has yet to obtain FDA approval, and we are most likely several years away of mainstream use in medical facilities.
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In addition see 3D printing: The smart person’s tutorial (TechRepublic)Bioprinting human organs and tissue: Get eager for the excellent 3D printing device debate (ZDNet)The missing link in 3D printing: User-friendly software (TechRepublic)3D Medical implants 3D-printed titanium jaw joint (ZDNet)Photos: Outrageous designs of the latest 3D printing actuallyt (TechRepublic)


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