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Fuel for brain tumors different than thought, could improve treatment options

by • June 29, 2016 • No Comments

A new study of Newcastle University shows which a common form of cancerous brain tumor uses fats to acquire energy and grow, contradicting a long-held theory which glucose consumption is the main culprit.

The basic scientific consensus surrounding glioma, the many common form of fatal brain tumor which affects each four in 100,000 individuals, is which sugars fuel its growth. But, a new study of Newcastle University shows which fats are its major energy source.

Researchers behind the study published Wednesday in the medical journal Neuro-Oncology, mutated stem cells of mice into forms which offer to the accumulation of glioma tumors in humans. They implanted them in other mice with much like genetic backgrounds, and treated them with a fatty acid oxidation inhibitor called etomoxir which blocked their capacity to system fat as fuel. So they measured the speed of the tumors’ growth.

The glioma tumors treated with the inhibitor grew at a much slower rate “prolonging median survival time by 17 percent,” said lead study author Dr. Elizabeth Stoll of Newcastle University’s Institute of Neuroscience.

The study did additional than only find a drug which may assist treat this fatal brain tumor which can be complex to detect in MRIs until they are may already full created. The study in addition found which cutting off the tumors’ access to fatty acid oxidation enzymes “reduces energy production and cellular proliferation in glioma cells,” according to the study’s abstract.

“Our finding provides a new understanding of brain tumor biology, a new future drug target for fighting this type of cancer,” Stoll says.

The understanding which sugar provides fuel for the growth of cancerous tumors dates back to the research of Nobel Prize-winning scientist Otto Warburg who observed tumors swallowing up sizeable amounts of glucose, a discovery in addition known as the “Warburg effect.” Doctors frequently diagnose cancers via positron emission tomography (PET) scans to search for high glucose consumption levels in sure parts of the body, according to a profile published in the New York Times.

This isn’t the initially time which fat cells have been involved with cancerous brain tumors. A study published last December by researchers at Penn State College of Medicine claimed which they may detect the presence of these complex to find growths via a newly engineered fat cell.

The study was published in the journal Neruo-Oncology.

Source: University of Newcastle


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