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Dual-sided pill stays put to release medication

by • April 7, 2016 • No Comments

A novel pill, created by researchers at MIT, shows promise in enabling for effective long-term delivery of drugs, with the talent to stick to the gastrointestinal tract for lengthy periods time. The pill manufactures use of a two-face create, with one side created to hold it in place, while the other repels liquid and food that may otherwise dislodge it.

The project is being led by MIT’s Robert Langer, who’s worked on much like projects in the past. Back in July 2015, his team generated a much likely-focutilized material, created to allow for single-use, ultra long-term drug delivery.

The new research is a step nearer to clinical use, providing a solution that – conceptually at very least – may allow for practical long-term medication delivery. Designed to reside in the gastrointestinal tract, the device manufactures use of a material called a mucoadhesive.

As the name suggests, the material is capable of sticking to the mucosal lining of organs. Its use has been trialled preceding, but has been discovered to be problematic, as food and liquids can easily become stuck to it, shifting it out of place preceding drugs can be delivered.

The researchers utilized a mucoadhesive polymer called Carbopol for one side of the pill, but for the other – the section tasked with repelling food and liquid – they utilized a cellulose acetate. That side was textured to mimic a lotus leaf, that has tiny protrusions that manufacture it incredibly hydrophobic. Once the texturing was achieve, the surface was flourinated and lubricated to manufacture it repel practically anything it comes into contact with.

The dual-sided pill was and so loaded with drugs and tested via intestinal tissue of pigs, alongside fully mucoadhesive and fully omniphobic pills. To simulate the environment in that the pills are created to function, the researchers flowed a mix of liquids and tiny piece of rice and bread along the tissue.

In testing, the omniphobic variant moved along the tissue in only a single 2nd, while the mucoadhesive pill stayed in place for seven 2nds preceding it was pulled out of place. The two-sided pill performed much advantageous, staying in place for the entire length of the experiment – a full 10 minutes.

With those positive results in the bag, the researchers plan to fine-tune the dual-sided pill, tweaking the amount of time it stays in place, as well as the rate of drug release. They in addition plan to tune the pill so that it attaches to specific sections of the GI tract.

Full details on the new study are published in the journal Advanced Healthcare Materials.

Source: MIT


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